Toxoplasmosis and Polygenic Disease Susceptibility Genes: Extensive Toxoplasma gondii Host/Pathogen Interactome Enrichment in Nine Psychiatric or Neurological Disorders

Table 6

Significantly enriched KEGG pathways within the overlapping interactome/susceptibility gene datasets (Signalling networks, metabolic pathways and neuronal pathways). 𝑃 values are provided after each pathway description.

	Signalling networks	Process	Metabolism	Neuronal
ADHD	Calcium signalling pathway 0.00442		Histidine metabolism 0.000162; Tryptophan metabolism 0.000473; Phenylalanine metabolism 0.00213; Biosynthesis of unsaturated fatty acids 0.0029; Tyrosine metabolism 0.00932	Dopaminergic synapse; 5.29𝐸−07; Cocaine addiction; 7.07𝐸−07Neuroactive ligand-receptor interaction 0.000559
Autism	VEGF signalling pathway	ECM-receptor interaction 0.000918; Cell adhesion molecules (CAMs) 0.00109; Focal adhesion 0.00239	None	Cocaine addiction 0.000086; Amphetamine addiction 0.00061; Dopaminergic synapse 0.00203; Serotonergic synapse 0.0079
Anorexia	None	None	None	Dopaminergic synapse 0.0000132; Cocaine addiction 0.000019; Neuroactive ligand-receptor interaction 0.000239; Amphetamine addiction 0.00296; Morphine addiction 0.00501; Serotonergic synapse 0.00924
Childhood obesity	PPAR signalling pathway 0.000011; p53 signalling pathway 0.00822	None	Glycerolipid metabolism 0.00525	None
Depression	Calcium signalling pathway 0.000239; Circadian rhythm—mammal 0.00546; VEGF signalling pathway 0.00618; Jak-STAT signalling pathway 0.00772; TGF-beta signalling pathway 0.00877	Osteoclast differentiation 0.000453; Apoptosis 0.000876; Gap junction 0.00104; Melanogenesis 0.00166	Tryptophan metabolism 0.0000468; Arginine and proline metabolism 0.00296; Phenylalanine metabolism 0.00366; Biosynthesis of unsaturated fatty acids 0.00498; alpha-Linolenic acid metabolism 0.00498; Histidine metabolism 0.00876	Dopaminergic synapse 0.000000000736; Cocaine addiction 0.0000000875; Amphetamine addiction 0.00000108; Serotonergic synapse 0.0000323; Morphine addiction 0.00104; Retrograde endocannabinoid signalling 0.00155; Neuroactive ligand-receptor interaction 0.00244; Glutamatergic synapse 0.00351; Long-term depression 0.00529
Bipolar disorder	Calcium signalling pathway 0.000384; Jak-STAT signalling pathway 0.00121	Apoptosis 0.0000464	Tyrosine metabolism 0.00306; Tryptophan metabolism 0.00354; Phenylalanine metabolism 0.00828	Dopaminergic synapse 0.00000000379; Cocaine addiction 0.0000000438; Amphetamine addiction 0.000000813; Neurotrophin signalling pathway 0.00292; Neuroactive ligand-receptor interaction 0.00496
Schizophrenia	Jak-STAT signalling pathway 0.00000299; MAPK signalling pathway 0.000558; VEGF signalling pathway 0.00077; PPAR signalling pathway 0.00395; Calcium signalling pathway 0.00444; Wnt signalling pathway 0.00661	Apoptosis 0.000000043; Osteoclast differentiation 0.00000285; Cell adhesion molecules (CAMs) 0.000787	Glutathione metabolism 0.00583	Cocaine addiction 0.0000000151; Dopaminergic synapse 0.0000000571; Amphetamine addiction 0.00000666; Glutamatergic synapse 0.000494; Serotonergic synapse 0.00944
Multiple sclerosis	Jak-STAT signalling pathway 0.000000000000259; TGF-beta signalling pathway 0.000492; MAPK signalling pathway 0.00126; ErbB signalling pathway 0.00382; p53 signalling pathway 0.00882	Osteoclast differentiation 0.000000000314; Cell adhesion molecules (CAMs) 0.0000000558; Apoptosis 0.0000000604
Alzheimer’s	PPAR signalling pathway 0.0000000416	Osteoclast differentiation 0.000351	Terpenoid backbone biosynthesis 0.00125; Arginine and proline metabolism 0.0028
Parkinson/s	MAPK signalling pathway 0.00623	Apoptosis 0.000537; Osteoclast differentiation 0.00246	Arginine and proline metabolism 0.00205; Histidine metabolism 0.00684	Dopaminergic synapse 0.0000000876; Cocaine addiction 0.000045; Amphetamine addiction 0.0034