Table 6: Significantly enriched KEGG pathways within the overlapping interactome/susceptibility gene datasets (Signalling networks, metabolic pathways and neuronal pathways). values are provided after each pathway description.

Signalling networksProcessMetabolismNeuronal

ADHDCalcium signalling pathway 0.00442Histidine metabolism 0.000162
Tryptophan metabolism 0.000473
Phenylalanine metabolism 0.00213
Biosynthesis of unsaturated fatty acids 0.0029
Tyrosine metabolism 0.00932
Dopaminergic synapse

Cocaine addiction 
Neuroactive ligand-receptor interaction 0.000559

AutismVEGF signalling pathway ECM-receptor interaction 0.000918
Cell adhesion molecules (CAMs) 0.00109
Focal adhesion 0.00239
NoneCocaine addiction 0.000086
Amphetamine addiction 0.00061
Dopaminergic synapse 0.00203
Serotonergic synapse 0.0079

AnorexiaNoneNoneNoneDopaminergic synapse 0.0000132
Cocaine addiction 0.000019
Neuroactive ligand-receptor interaction 0.000239
Amphetamine addiction 0.00296
Morphine addiction 0.00501
Serotonergic synapse 0.00924

Childhood obesityPPAR signalling pathway 0.000011
p53 signalling pathway 0.00822
NoneGlycerolipid metabolism 0.00525None

DepressionCalcium signalling pathway 0.000239
Circadian rhythm—mammal 0.00546
VEGF signalling pathway 0.00618
Jak-STAT signalling pathway 0.00772
TGF-beta signalling pathway 0.00877
Osteoclast differentiation 0.000453
Apoptosis 0.000876
Gap junction 0.00104
Melanogenesis 0.00166
Tryptophan metabolism 0.0000468
Arginine and proline metabolism 0.00296
Phenylalanine metabolism 0.00366
Biosynthesis of unsaturated fatty acids 0.00498
alpha-Linolenic acid metabolism 0.00498
Histidine metabolism 0.00876
Dopaminergic synapse 0.000000000736
Cocaine addiction 0.0000000875
Amphetamine addiction 0.00000108
Serotonergic synapse 0.0000323
Morphine addiction 0.00104
Retrograde endocannabinoid signalling 0.00155
Neuroactive ligand-receptor interaction 0.00244
Glutamatergic synapse 0.00351
Long-term depression 0.00529

Bipolar disorderCalcium signalling pathway 0.000384
Jak-STAT signalling pathway 0.00121
Apoptosis 0.0000464Tyrosine metabolism 0.00306
Tryptophan metabolism 0.00354
Phenylalanine metabolism 0.00828
Dopaminergic synapse 0.00000000379
Cocaine addiction 0.0000000438
Amphetamine addiction 0.000000813
Neurotrophin signalling pathway 0.00292
Neuroactive ligand-receptor interaction 0.00496

SchizophreniaJak-STAT signalling pathway 0.00000299
MAPK signalling pathway 0.000558
VEGF signalling pathway 0.00077
PPAR signalling pathway 0.00395
Calcium signalling pathway 0.00444
Wnt signalling pathway 0.00661
Apoptosis 0.000000043
Osteoclast differentiation 0.00000285
Cell adhesion molecules (CAMs) 0.000787
Glutathione metabolism 0.00583Cocaine addiction 0.0000000151
Dopaminergic synapse 0.0000000571
Amphetamine addiction 0.00000666
Glutamatergic synapse 0.000494
Serotonergic synapse 0.00944

Multiple sclerosisJak-STAT signalling pathway 0.000000000000259
TGF-beta signalling pathway 0.000492
MAPK signalling pathway 0.00126
ErbB signalling pathway 0.00382
p53 signalling pathway 0.00882
Osteoclast differentiation 0.000000000314
Cell adhesion molecules (CAMs) 0.0000000558
Apoptosis 0.0000000604

Alzheimer’sPPAR signalling pathway 0.0000000416Osteoclast differentiation 0.000351Terpenoid backbone biosynthesis 0.00125
Arginine and proline metabolism 0.0028

Parkinson/sMAPK signalling pathway 0.00623Apoptosis 0.000537
Osteoclast differentiation 0.00246
Arginine and proline metabolism 0.00205
Histidine metabolism 0.00684
Dopaminergic synapse 0.0000000876
Cocaine addiction 0.000045
Amphetamine addiction 0.0034