Journal of Pharmaceutics

Review Article

Microencapsulation for the Therapeutic Delivery of Drugs, Live Mammalian and Bacterial Cells, and Other Biopharmaceutics: Current Status and Future Directions

Table 3

Microencapsulated mammalian cell formulations for therapeutic applications.
Disease conditionMicrocapsule typeEncapsulated cells typeDelivery method and modelsReference(s)
Type 1 diabetes mellitusAlginate polylysineRat PICsRat intraperitoneal transplant[22]
APARat PICsRat intraperitoneal transplant[23]
APARat PICsIn vitro [24]
  Mouse intraperitoneal transplant 
Agarose Mouse PICsDirectly onto the mouse omentum [25]
Barium alginatePorcine NPCCsMouse intraperitoneal transplant[26]
APAPorcine PICsCanine abdominal transplant[27]
Barium alginateHuman PICsHuman intraperitoneal transplant[28]
APAPorcine PICsHuman intraperitoneal transplant[29]
Alginate poly-L-ornithineHuman PICsHuman intraperitoneal transplant[30]
Hepatic diseaseAPARat hepatocytesRat intraperitoneal transplant[31]
APARat hepatocytesMouse intraperitoneal transplant[32]
APARat hepatocytes and human FLSCsMouse intraperitoneal transplant[33]
APAPorcine hepatocytesMouse intraperitoneal transplant[34]
APAHuman umbilical cord blood cellsRat intraperitoneal transplant[35]
Cardiovascular diseaseAPACHO cellsRat intramyocardial injection[36]
APARat mesenchymal stem cellsRat intramyocardial injection[37]
Parathyroid insufficiencyBarium alginateHuman parathyroid tissueHuman forearm and leg transplant[38]
Barium alginateRat parathyroid tissueRat paravertebral muscle transplant[39]
Barium alginateHuman parathyroid tissueHuman brachioradial muscle[40]
AnemiaPolyether-sulfoneMouse myoblast cellsMouse dorsal flank transplant[41]
Polyether-sulfoneMouse myoblast cellsMouse dorsal flank transplant[42]
 Polyether-sulfoneHuman erythroleukemia cells and mouse melanoma cellsMouse subcutaneous/extraperitoneal transplant[43]
 APACanine kidney cellsMouse intraperitoneal injection[44]
 APACHO cellsMouse intraperitoneal transplant[45]
 APACHO cellsMouse intraperitoneal injection[46]
 Alginate polylysinePorcine aortic endothelial cellsMouse subcutaneous injection[47]
 APAGenetically modified hamster kidney cellsMouse subcutaneous injection[48]
CancerAlginate-polylysineHuman genetically engineered fetal kidney cellsMouse subcutaneous flank injection[49]
 APAHuman embryonic genetically engineered kidney cellsMouse subcutaneous flank injection[50]
 APAMouse myoblastsMouse subcutaneous flank injection[51]
 AlginateHuman fetal genetically engineered kidney cellsRat intracerebral implantation[52]
 APAMouse genetically engineered myoblastsMouse intraperitoneal injection[53]
 Alginate-polylysinePorcine aortic endothelial cellsMouse subcutaneous injection[54]
 AlginateGenetically engineered CHO cellsRat intraperitoneal injection[55]
 APAMouse genetically engineered myeloma cellsRat subcutaneous injection[56]
Neurodegenerative diseasesAPABaby hamster kidney cellsMouse cerebral cortex implantation[57]
 AlginateNeonatal porcine choroid plexus cellsRat intracranial transplantation[58]