Transdermal Delivery of Small Interfering RNA with Elastic Cationic Liposomes in Mice

Figure 2

The suppression of luciferase activity (a) and cytotoxicity (b) after siRNA transfection by elastic cationic liposomes. In (a), cationic lipoplexes were added to FL-SiHa cells at 50 nM siRNA. The luciferase assay was carried out 48 h after incubation of the lipoplexes. Statistical significance was evaluated by Student’s 𝑡-test. ^∗𝑃<0.05, ^∗∗𝑃<0.01, and ^∗∗∗𝑃<0.001, compared with lipoplex of Cont siRNA. In (b), cytotoxicity was evaluated 48 h after transfection. In (a) and (b), each column represents the mean ± S.D. (𝑛=3).

(a)

(b)