Transdermal Delivery of Small Interfering RNA with Elastic Cationic Liposomes in Mice

Table 1

Particle size and 𝜁-potential of liposomes and lipoplexes used in this study.

Vesicles	% (w/w)			Liposome^a			Lipoplex^a,b
	DOTAP	NaChol^c	Tween 80	Size (nm)	PD^d	𝜁-potential (mV)	Size (nm)	PD^d
DOTAP	100	—	—	109±2	0.10±0.02	40.2±2.4	1724±123	0.63±0.04
C5	95	5	—	84±2	0.11±0.02	42.4±1.4	1795±432	0.65±0.13
C10	90	10	—	87±3	0.16±0.00	52.2±2.2	1809±161	0.61±0.05
C15	85	15	—	82±1	0.13±0.01	47.8±1.7	1859±115	0.56±0.02
T5	95	—	5	82±1	0.19±0.01	36.0±0.8	582±138	0.26±0.04
T10	90	—	10	87±1	0.17±0.01	26.4±1.8	550±45	0.26±0.01
T15	85	—	15	83±2	0.15±0.01	30.8±1.5	775±106	0.33±0.04

aIn water. ^bWeight ratio of lipid/siRNA = 14/1. ^cNaChol, sodium cholate. ^dPD, polydispersity index. Values represent means ± S.D. (𝑛=3).