Artemether-Soluplus Hot-Melt Extrudate Solid Dispersion Systems for Solubility and Dissolution Rate Enhancement with Amorphous State Characteristics

Table 2

Order of drug release of various formulations determined by the regression coefficients.

Formulation types	Zero order	First order	Higuchi	Hixon Crowell	Krosmeyer Peppas
	(𝑟^2)	(𝑟^2)	(𝑟^2)	(𝑟^2)	(𝑟^2)
F1	0.6792	0.2568	0.9976	0.7190	0.2289
F2	0.5726	0.2415	0.9979	0.7351	0.3656
F3	0.5573	0.3475	0.9980	0.7440	0.3860
F4	0.5814	0.3512	0.9973	0.7378	0.1193
F5	0.5664	0.3529	0.9980	0.7449	0.2946
F6	0.5664	0.3531	0.9986	0.6740	0.5579
F7	0.6371	0.4142	0.9952	0.7007	0.8875
F8	0.6192	0.4152	0.9955	0.8026	0.7095
F9	0.6098	0.4587	0.9962	0.7500	0.5500
F10	0.6630	0.2154	0.9940	0.6945	0.9685
F11	0.6005	0.2167	0.9969	0.7964	0.9265
F12	0.5640	0.2254	0.9983	0.7950	0.6851
F13	0.5754	0.2298	0.9980	0.7879	0.4377
F14	0.5709	0.3697	0.9974	0.6631	0.4857
F15	0.5807	0.4589	0.9969	0.6703	0.9735