Artemether-Soluplus Hot-Melt Extrudate Solid Dispersion Systems for Solubility and Dissolution Rate Enhancement with Amorphous State Characteristics

Table 8

Representation of the powder flow characteristics of various formulations.

Formulation	(Angle of repose θ)	Bulk density	Tapped density	Hausner’s ratio	Carr’s index
F1	20.61	0.3586	0.4428	1.23	19.01
F2	20.54	0.3581	0.4416	1.23	18.91
F3	21.14	0.3612	0.4366	1.2	17.26
F4	20.96	0.3508	0.4025	1.14	12.84
F5	20.1	0.3434	0.3996	1.16	14.07
F6	20.61	0.3484	0.4035	1.15	13.65
F7	21.48	0.3503	0.4016	1.14	12.75
F8	18.74	0.3516	0.4048	1.15	13.15
F9	19.23	0.3403	0.3852	1.13	11.64
F10	20.27	0.3852	0.4752	1.23	18.95
F11	21.23	0.3861	0.4739	1.22	18.53
F12	18.49	0.3776	0.4444	1.17	15.03
F13	18.39	0.3663	0.4428	1.2	17.28
F14	17	0.3367	0.3987	1.18	15.55
F15	16.32	0.3419	0.3952	1.15	13.47