Artemether-Soluplus Hot-Melt Extrudate Solid Dispersion Systems for Solubility and Dissolution Rate Enhancement with Amorphous State Characteristics

Table 9

In vitro antimalarial activity of various formulations.

Formulation codes	IC50 (ng/mL) (in vitro whole cell SYBR assay study)	Chloroquine-sensitive cell line (ng/mL) 3D7
F1	0.062	0.0000089
F2	0.059	0.0000078
F3	0.054	0.0000067
F4	0.069	0.0000098
F5	0.064	0.0000088
F6	0.059	0.0000076
F7	0.074	0.0000099
F8	0.071	0.0000094
F9	0.068	0.0000081
F10	0.081	0.0000095
F11	0.078	0.0000085
F12	0.074	0.0000065
F13	0.065	0.0000058
F14	0.058	0.0000039
F15	0.056	0.0000028
ARTM	2.1	0.00068
Chloroquine	3.8	0.0025