Cellular Redox Status Regulates Emodin-Induced Radiosensitization of Nasopharyngeal Carcinoma Cells In Vitro and In Vivo
Table 4
Effects of emodin and radiation on apoptosis and cell cycle progression of CNE-1 cells () %.
Groups
G0/G1
G2/M
SI
Apoptosis
Control
70.53 ± 1.34
10.21 ± 0.66
19.26 ± 0.86
—
10.1 ± 2.1
Hypoxia
72.16 ± 3.73
5.81 ± 0.15
22.03 ± 1.12
1.79
11.2 ± 0.8
Emodin
68.73 ± 0.67
7.41 ± 0.14
23.86 ± 1.16
1.34
10.9 ± 1.4
2 Gy
68.27 ± 3.34
14.50 ± 0.25
17.14 ± 0.64
0.68
15.9 ±
Hypoxia + emodin
68.91 ± 1.32
8.01 ± 0.21
23.12 ± 1.35
1.24
13.8 ± 1.7
Hypoxia + 2 Gy
69.27 ± 2.62
13.91 ± 0.17
16.81 ± 0.82
0.72
13.6 ± 0.7
Emodin + 2 Gy
67.24 ± 1.64
20.51 ± 1.02
12.19 ± 0.14
0.47*
22.8 ± 1.8⋆
Emodin + hypoxia + 2 Gy
63.33 ± 1.79
21.14 ± 1.21
15.53 ± 0.32
0.43*
18.7 ± 1.3⋆
SI (sensitivity index) = (experimental group /)/(control group /); *SI ≤ 0.5, indicated by the duration of phase. P < 0.05 compared with hypoxic cells group.
