Optimization of Carboxymethyl-Xyloglucan-Based Tramadol Matrix Tablets Using Simplex Centroid Mixture Design

Figure 6

Contour plot showing amount of drug release at second hour (𝑌₁) using different combinatinon, of 𝑋₁, 𝑋₂, and 𝑋₃. The contour lines showing percentage of drug release at the end of second hour.

(a)   3D graph of percent drug release at 2nd hour

(b) Contour plot for percent drug release at 2nd hour