Optimization of Carboxymethyl-Xyloglucan-Based Tramadol Matrix Tablets Using Simplex Centroid Mixture Design

Table 1

Trial batch formulations from 𝐴₁ to 𝐴₅.

Ingredients	Formulations
	𝐴1	𝐴2	𝐴3	𝐴4	𝐴5
Tramadol HCl	100	100	100	100	100
TSP	50	100	150	200	250
HPMC K100M	—	—	—	—	—
DCP	20	20	20	20	20
Talc	5	5	5	5	5
Magnesium Stearate	5	5	5	5	5
PVP K-30	30	30	30	30	30
Isopropyl alcohol	qs.	qs.	qs.	qs.	qs.
Total	210	260	310	360	410

All quantities in mg.