Optimization of Carboxymethyl-Xyloglucan-Based Tramadol Matrix Tablets Using Simplex Centroid Mixture Design

Table 5

Dissolution model for 𝐹₁ to 𝐹₂ formulations.

Batch code	Release exponent (n)	Kinetic constant (K)	R	Best fit model
𝐹3	0.5919	30.8556	0.9874	Matrix
𝐹4	0.5030	36.2863	0.9828	Matrix
𝐹5	0.5171	31.8826	0.9845	Matrix
𝐹6	0.5008	29.6438	0.9870	Matrix
𝐹7	0.5301	27.1364	0.9897	Matrix
𝐹1−𝐹7	0.5814	36.9647	0.9955	Matrix
𝐹1	0.5049	36.9443	0.9957	Matrix

Non-Fickian.