Research Article
Optimization of Carboxymethyl-Xyloglucan-Based Tramadol Matrix Tablets Using Simplex Centroid Mixture Design
Table 6
Pre- and postcompression properties of optimization batches
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| | Parameters | | | | | | | |
| | Bulk density (g/mL) | 0.387 ± 0.22 | 0.355 ± 0.17 | 0.303 ± 0.11 |
0.409 ± 0.30 | 0.343 ± 0.11 | 0.318 ± 0.16 | 0.366 ± 0.15 | | Tapped density (g/mL) | 0.442 ± 0.14 | 0.416 ± 0.35 | 0.426 ± 0.03 | 0.493 ± 0.26 | 0.428 ± 0.05 | 0.374 ± 0.04 | 0.412 ± 0.04 | | Angle of repose | 27.78 ± 0.14 | 26.05 ± 0.08 | 25.55 ± 0.12 | 29.85 ± 0.02 | 28.08 ± 0.16 | 27.08 ± 0.08 | 26.06 ± 0.04 | | Carr’s index | 13.44 ± 0.14 | 12.66 ± 0.11 | 12.3 ± 0.16 | 14.43 ± 0.13 | 14.06 ± 0.12 | 13.97 ± 0.17 | 12.17 ± 0.15 | | Hausner’s ratio | 1.14 ± 0.18 | 1.17 ± 0.28 | 1.41 ± 0.07 | 1.21 ± 0.28 | 1.24 ± 0.08 | 1.17 ± 0.13 | 1.13 ± 0.11 | | Hardness (kg/cm2) | 5.1 ± 0.33 | 5.3 ± 0.26 | 5.5 ± 0.18 | 5.4 ± 0.34 | 5.7 ± 0.17 | 5.5 ± 0.32 | 5.4 ± 0.13 | | Friability | 0.74 ± 0.21 | 0.70 ± 0.11 | 0.57 ± 0.22 | 0.62 ± 0.16 | 0.42 ± 0.12 | 0.52 ± 0.23 | 0.67 ± 0.22 | | Uniformity of weight (mg) | 378.29 ± 0.34 | 379.78 ± 0.45 | 378.98 ± 0.55 | 381.19 ± 0.36 | 382.4 ±
0.12 | 378.56 ± 0.24 | 381.78 ± 0.13 | | Drug content (%) | 100.22 ± 0.22 | 100.62 ± 0.11 | 99.14 ± 0.18 | 98.34 ± 0.39 | 98.72 ± 0.21 | 101.16 ± 0.67 | 98.52 ± 0.89 | | Thickness (mm) | 4.40 ± 0.014 | 4.17 ± 0.016 | 3.89 ± 0.026 | 4.29 ± 0.016 | 4.02 ± 0.031 | 4.22 ± 0.014 | 3.83 ± 0.034 |
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±SD (standard deviation) .
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