Research Article
Optimization of Carboxymethyl-Xyloglucan-Based Tramadol Matrix Tablets Using Simplex Centroid Mixture Design
Table 8
Pre- and postcompression properties of optimized carboxymethyl xyloglucan matrix tablets.
| | Parameters | | | |
| | Bulk density | 0.312 ± 0.19 | 0.331 ± 0.22 | 0.376 ± 0.16 | | Tapped density | 0.351 ± 0.24 | 0.348 ± 0.13 | 0.397 ± 0.09 | | Angle repose | 25.03 ± 0.07 | 27.31 ± 0.11 | 29.27 ± 0.03 | | Carr’s index | 13.01 ± 0.20 | 13.22 ± 0.17 | 14.21 ± 0.13 | | Hausner’s ratio | 1.12 ± 0.21 | 1.05 ± 0.19 | 1.06 ± 0.14 | | Hardness | 5.2 ± 0.03 | 5.1 ± 0.01 | 5.3 ± 0.04 | | Friability | 0.542 ± 0.07 | 0.481 ± 0.16 | 0.768 ± 0.18 | | Weight variation | 365 ± 1.79 | 387 ± 0.93 | 395 ± 1.04 | | Drug content | 99.69 ± 0.17 | 98.61 ± 0.02 | 98.14 ± 0.11 | | Thickness (mm) | 3.82 ± 0.03 | 3.96 ± 0.06 | 4.17 ± 0.01 |
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±SD (standard deviation) .
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