Research Article
Simultaneous Determination of Clidinium Bromide and Chlordiazepoxide in Combined Dosage Forms by High-Performance Liquid Chromatography
Table 3
Accuracy and precision of within- and between-run analysis for the determination of clidinium bromide and chlordiazepoxide by HPLC.
| | Nominal concentration (g mL−1) | Intra-day () | Inter-day () | | Mean ± SD μg mL−1 | RSD (%) | Recovery (%) | Mean ± SD μg mL−1 | RSD (%) | Recovery (%) |
| | | Clidinium bromide |
| | 2.50 | |
3.17
|
100.80
| |
2.79
|
100.40
| | 6.50 | |
2.09
|
102.77
| |
2.53
|
103.38
| | 25.00 | |
1.99
|
102.52
| |
1.09
|
102.96
| | 50.00 | |
1.47
|
101.72
| |
0.77
|
101.22
| | 75.00 | |
1.27
|
101.04
| |
0.56
|
101.51
| | 150.00 | |
0.60
|
100.61
| |
0.49
|
101.12
| | 300.00 | |
0.14
|
100.64
| |
0.57
|
100.93
|
| | | Chlordiazepoxide |
| | 3.00 | |
2.94
|
102.00
| |
2.63
|
101.33
| | 12.00 | |
1.15
|
101.08
| |
1.98
|
100.83
| | 25.00 | |
0.92
|
100.48
| |
1.15
|
100.80
| | 60.00 | |
0.89
|
100.96
| |
0.95
|
101.63
| | 125.00 | |
0.35
|
100.04
| |
0.53
|
100.34
| | 250.00 | |
0.22
|
100.03
| |
0.35
|
99.98
| | 500.00 | |
0.18
|
105.59
| |
0.21
|
103.97
|
|
|
