Antibacterial Derivatives of Ciprofloxacin to Inhibit Growth of Necrotizing Fasciitis Associated Penicillin Resistant Escherichia coli

Figure 1

Comparative molecular structures of ciprofloxacin and ester derivatives. Drug 2 is the n-propyl derivative followed by drug 3 (n-pentyl derivative) and drug 4 (n-octyl derivative). The formation of an ester group (–C(O)OR) to replace the original carboxyl group (–C(O)OH) and the type of ester moiety imparts substantial changes in molecular properties. The alteration in molecular properties involves descriptors such as Log P, polar surface area, molecular weight, and molecular volume. Beneficial changes will enhance drug likeness of the medicament.