Antibacterial Derivatives of Ciprofloxacin to Inhibit Growth of Necrotizing Fasciitis Associated Penicillin Resistant Escherichia coli
Figure 2
Inhibition of penicillin-resistant Escherichia coli by parent ciprofloxacin and combinations of parent ciprofloxacin with various ester derivatives. Note that the observed bacterial death rate is greater than 60% (e.g., percent survival less than 40%) at concentrations less than 1 microgram per milliliter for all combinations. The rate of bacterial death is greater than 80% at concentrations greater than one microgram per milliliter for all combinations. Ciprofloxacin with ester derivatives incurs bacterial death with the additional benefit of enhanced tissue penetration of the antibacterial. Drug combinations are describe previously , , (3), (4), and (5).
