Research Article

Antibacterial Derivatives of Ciprofloxacin to Inhibit Growth of Necrotizing Fasciitis Associated Penicillin Resistant Escherichia coli

Figure 3

Enhanced tissue penetration over time period of 7 hours utilizing the dermal permeability coefficient ( ) and the dermal absorbed dose per event for each compound. Note that the depth of penetration into tissue increases per time period of 7 hours as the length of the ester moiety (aliphatic) increases. The penetration of tissue is greatly enhanced with the placement of an n-octyl ester moiety in place of the original carboxyl group of parent ciprofloxacin. The enhancement of tissue penetration by the n-propyl, n-pentyl, and vast improvement by n-octyl ester derivatives of the broad-spectrum ciprofloxacin will powerfully improve the distribution of the antibacterial medicament within infected tissue.
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