Antibacterial Derivatives of Ciprofloxacin to Inhibit Growth of Necrotizing Fasciitis Associated Penicillin Resistant Escherichia coli
Figure 3
Enhanced tissue penetration over time period of 7 hours utilizing the dermal permeability coefficient () and the dermal absorbed dose per event for each compound. Note that the depth of penetration into tissue increases per time period of 7 hours as the length of the ester moiety (aliphatic) increases. The penetration of tissue is greatly enhanced with the placement of an n-octyl ester moiety in place of the original carboxyl group of parent ciprofloxacin. The enhancement of tissue penetration by the n-propyl, n-pentyl, and vast improvement by n-octyl ester derivatives of the broad-spectrum ciprofloxacin will powerfully improve the distribution of the antibacterial medicament within infected tissue.