Antibacterial Derivatives of Ciprofloxacin to Inhibit Growth of Necrotizing Fasciitis Associated Penicillin Resistant Escherichia coli

Table 3

Penetration of tissue (superficial fascia and BBB).

Drug	Log BB	BB	Dermal Permeability Coefficient 𝐾𝑝 (centimeter/hour)
Drug 1, ciprofloxacin	−1.07	0.085	2.87𝐸−05
Drug 2, propyl ester	−0.735	0.184	1.29𝐸−03
Drug 3, Pentyl Ester	−0.574	0.267	4.32𝐸−03
Drug 4, octyl ester	−0.343	0.454	26.6𝐸−03