Design, Development, and Optimization of Sterculia Gum-Based Tablet Coated with Chitosan/Eudragit RLPO Mixed Blend Polymers for Possible Colonic Drug Delivery

Table 5

Comparison of pharmacokinetic parameters obtained after oral administration of three different formulations of AZA in rabbits with an equivalent dose of 50 mg/Kg.

Pharmacokinetic	MKT tablet; of AZA	EC tablet of AZA	MCDDS
parameters
AUC0-∞	2130.76	2678.13	3380.41
𝐶max (ng/mL)	1430.08	847.5	453.56
𝑇max (h)	1.50	5.00	9.00
Ke (h^−1)	1.024	0.0911	0.0501
(𝑡1/2)^e (h)	0.6820	7.59	12.95
AUMC0-∞ (h^2·ng/mL)	7670.73	17729.22	46677.81
MRT (h)	3.60	6.62	13.81
Ka (h^−1)	3.18	5.6	11.8
(𝑡1/2)^a (h)	0.2179	0.1239	0.0587
𝑉𝑑 (L)	2.26	7.80	12.71
TCR (L/h/kg)	2.31	0.7105	0.6367