Research Article
Study on Mixed Solvency Concept in Formulation Development of Aqueous Injection of Poorly Water Soluble Drug
Table 1
pH dependent solubility of zaltoprofen at room temperature.
| Buffer solutions | Solubility* (mg/mL) |
| Distilled water | 0.072 ± 0.012 | Hydrochloric acid buffer pH 1.2 | 0.0134 ± 0.018 | Hydrochloric acid buffer pH 2.2 | 0.0196 ± 0.006 | Acid phthalate buffer pH 4.0 | 0.0285 ± 0.014 | Phosphate buffer pH 5.8 | 0.0384 ± 0.007 | Phosphate buffer pH 8.0 | 0.2067 ± 0.013 | Alkaline borate buffer pH 9.0 | 1.0241 ± 0.12 | Alkaline borate buffer pH 10.0 | 1.376 ± 0.011 |
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Average of 3 determinations.
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