Ufasomes Mediated Cutaneous Delivery of Dexamethasone: Formulation and Evaluation of Anti-Inflammatory Activity by Carrageenin-Induced Rat Paw Edema Model

Table 1

Size and entrapment efficiency of the prepared oleic acid vesicles.

Formulation code	Oleic acid : drug	EE (%)	Particle size (nm)	PDI	Turbidity (500 N.T.U.)	Zeta potential (mV)
UF-1	9 : 1	39.6 ± 2.1	502 ± 18	0.321 ± 0.021	415 ± 10	−11.8 ± 0.9
UF-2	8 : 2	65.2 ± 3.8	631 ± 15	0.534 ± 0.026	387 ± 12	−6.8 ± 0.9
UF-3	7 : 3	53.4 ± 2.7	537 ± 16	0.284 ± 0.015	395 ± 8	−13.8 ± 0.9
UF-4	6 : 4	48.4 ± 2.5	525 ± 11	0.476 ± 0.029	421 ± 11	−7.8 ± 0.9
UF-5	5 : 5	44.5 ± 2.2	450 ± 13	0.438 ± 0.019	407 ± 10	−12.8 ± 0.4
LIPO CHL : PC	1 : 5	42.6 ± 2.4	474 ± 12	0.519 ± 0.022	392 ± 13	−2.8 ± 0.9

UF-1, 2, 3, 4, 5: ufasomal formulations, CHL: cholesterol, PC: phosphatidylcholine, EE: entrapment efficiency, PDI: polydispersity index, N.T.U.: nephelometric turbidity unit.