Preparation and Characterization of Self-Microemulsifying Drug Delivery System of Olmesartan Medoxomil for Bioavailability Improvement

Table 2

Solubility of olmesartan medoxomil in few oils, surfactants, and cosurfactants.

Vehicle	Function in SMEDDS	Avg. solubility*
		(mg/mL)
Capmul MCM	Oil	0.26±0.01
Sunflower oil	Oil	0.358±0.020
Castor oil	Oil	0.500±0.045
Plurol Olieque	Oil	0.79±0.23
Labraphil	Oil	0.76±0.09
Lauroglycol	Surfactant	0.87±0.02
Transcutol	Cosurfactant	36.4±1.01
Captax200	Surfactant	0.29±0.03
Captax355	Surfactant	0.69±0.13
Propylene glycol	Cosurfactant	1.3±0.77
Tween 80	Surfactant	73±2.08
Tween 60	Surfactant	58±1.89
Acconon C80	Cosurfactant	8.2±0.31
Acrysol EL135	Oil	72.4±2.31
PEG 200	Co-surfactant	1.52±0.98
PEG 400	Co-surfactant	6.2±0.95

*Values are expressed as mean ± SD (𝑛=3).