Preparation, Characterization, and In Vivo Evaluation of Olanzapine Poly(D,L-lactide-co-glycolide) Microspheres

Table 1

Properties of Olanzapine PLGA microspheres.

Formulation	A	B	C	D
PLGA type	75 : 25	50 : 50	65 : 35	75 : 25
Polymer MW	15 kDa	30 kDa	82 kDa	131 kDa
Drug content, %	26	30	40	40
Bulk density, g/mL	0.59	0.70	0.60	0.96
Mean particle size (μm)	17.0	16.8	22.3	20.6
Dose of Olanzapine	10 mg/kg	10 mg/kg	20 mg/kg	20 mg/kg