Quantum Dot-Loaded Liposomes to Evaluate the Behavior of Drug Carriers after Oral Administration

Figure 1

Physicochemical properties of hydrophobic (unmodified) QD-loaded SA liposomes. The lipid composition was DSPC : SA : Chol (= 8 : 0.2 : 1). Photographs of QD-loaded liposomes in phosphate buffer, (A) liposomes without QD before ultracentrifugation, (B) liposomes without QD after ultracentrifugation, and (C) 100 nM, (D) 200 nM, and (E) 400 nM QD-loaded liposomes after ultracentrifugation. All photographs were captured by placing the samples under a UV lamp. (F) TEM image of QD-loaded liposomes. The scale bar is 100 nm. (G) The fluorescence spectrum of QD-loaded liposomes was measured in phosphate buffer. Excitation was performed at 480 nm.