Research Article
Development and Evaluation of Dual Cross-Linked Pulsatile Beads for Chronotherapy of Rheumatoid Arthritis
Table 1
Composition of single and dual cross-linked beads formulation.
| Batch code | Dispersion phase | Dispersion medium | Lornoxicam (mg) | Sodium alginate (mg) | Pectin (mg) | Distilled water (mL) | CaCl2 (% w/v) | AlCl3 (% w/v) | Cross linking time (min.) |
| P1 | 50 | 400 | 100 | 10 | 5 | — | 10 | P2 | 50 | 350 | 150 | 10 | 5 | — | 10 | P3 | 50 | 300 | 200 | 10 | 5 | — | 10 | P4 | 50 | 450 | 50 | 10 | 5 | — | 10 | P5 | 50 | 250 | 250 | 10 | 5 | — | 10 | P6 | 50 | 400 | 100 | 10 | 5 | 5 | 10 | P7 | 50 | 450 | 50 | 10 | 5 | 5 | 10 | P8 | 50 | 400 | 100 | 10 | 5 | — | 15 | P9 | 50 | 400 | 100 | 10 | 5 | — | 20 |
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