Dissolution Rate Enhancement, Design and Development of Buccal Drug Delivery of Darifenacin Hydroxypropyl <i>β</i>-Cyclodextrin Inclusion Complexes

<table class="table-group" id="tab10"><tr><td><table class="table"><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr class="thead"><td align="left">Complexes</td><td align="center">Best fit model</td><td align="center"><span style="width: 8.6625004px;"><svg height="7.9499998" id="M130" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 8.6625004 7.9499998" width="8.6625004" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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q42 56 97 103.5t96 71.5q46 26 74 26q9 0 16 -2.5t14 -11.5t9.5 -24.5t-1 -44t-13.5 -68.5q-30 -117 -47 -200q-4 -19 -3.5 -25t6.5 -6q21 0 70 48z" id="x1D45B"></path></g>
</svg></span></td><td align="center"><span style="width: 17.4px;"><svg height="15.975" id="M131" style="vertical-align:-0.1092pt" version="1.1" viewbox="0 0 17.4 15.975" width="17.4" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,15.775)"><path d="M627 18l-10 -26q-79 6 -116 27t-69 76q-41 71 -71 138q-13 29 -27.5 39t-42.5 10h-46l-27 -145q-13 -74 -2.5 -88.5t78.5 -20.5l-6 -28h-271l5 28q66 6 82.5 21.5t30.5 87.5l71 387q12 66 2 78.5t-77 19.5l8 28h233q102 0 147 -29q65 -43 65 -129q0 -69 -45.5 -117
t-115.5 -72q40 -86 66 -133q39 -68 65 -101q28 -37 73 -51zM491 483q0 67 -33.5 101t-91.5 34q-35 0 -51 -10q-13 -8 -20 -48l-45 -245h49q71 0 113 28q79 52 79 140z" id="x1D445"></path></g>
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</svg></span></td></tr><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr><td align="left">D</td><td align="center">Zero order</td><td align="center">1.0032</td><td align="center">0.9947</td></tr><tr><td align="left">Ha1</td><td align="center">Peppas</td><td align="center">0.86378</td><td align="center">0.9378</td></tr><tr><td align="left">Ha2</td><td align="center">Peppas</td><td align="center">0.9642</td><td align="center">0.9858</td></tr><tr><td align="left">Ha3</td><td align="center">Peppas</td><td align="center">0.9326</td><td align="center">0.9943</td></tr><tr><td align="left">Ha4</td><td align="center">Zero order</td><td align="center">1.021</td><td align="center">0.9842</td></tr><tr><td align="left">Ha5</td><td align="center">Zero order</td><td align="center">1.001</td><td align="center">0.9955</td></tr><tr class="table-tr"><td colspan="4"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

Diffusion parameter of HPMC K100M CR formulations.

Journal of Pharmaceutics

tab10

Table 10

Table 10: Dissolution Rate Enhancement, Design and Development of Buccal Drug Delivery of Darifenacin Hydroxypropyl <i>β</i>-Cyclodextrin Inclusion Complexes 

Table 10 | Dissolution Rate Enhancement, Design and Development of Buccal Drug Delivery of Darifenacin Hydroxypropyl β-Cyclodextrin Inclusion Complexes 