Dissolution Rate Enhancement, Design and Development of Buccal Drug Delivery of Darifenacin Hydroxypropyl β-Cyclodextrin Inclusion Complexes

Table 3

Gibbs free energy of transfer (Δ𝐺^∘_tr) for solubilization process of darifenacin in aqueous solutions of Hpβ-CD at 37°C.

Moles of β-CD in water	Δ𝐺^∘tr (kJ/mol)
0.0025	−0.614
0.005	−1.08
0.01	−1.867
0.015	−2.506