Dissolution Rate Enhancement, Design and Development of Buccal Drug Delivery of Darifenacin Hydroxypropyl β-Cyclodextrin Inclusion Complexes

Table 4

Evaluation parameter of complexes.

Drug: Hp𝛽-CD Complex	% Practical Yield	% Drug Content	Saturation Solubility (mg/mL)	% Increase in solubility
Drug	—	—	3.14	—
Physical mixture	87.17±2.17	92.11±1.34	8.58	273.24±4.64
Kneading	84.12±1.83	95.32±2.14	8.24	262.42±5.79
Co-grounding	85.03±1.98	89.59±1.58	8.31	264.64±3.98
Co-evaporation	78.17±1.71	93.88±1.74	12.13	386.30±4.55
Melting method	82.43±2.76	88.7±1.89	9.17	292.03±5.75
Freeze-Drying	86.12±2.49	95.24±3.57	20.71	659.55±8.47
Spray Drying	42.54±3.27	86.88±2.63	16.54	526.75±7.33