Research Article
Dissolution Rate Enhancement, Design and Development of Buccal Drug Delivery of Darifenacin Hydroxypropyl β-Cyclodextrin Inclusion Complexes
Table 4
Evaluation parameter of complexes.
| Drug: Hp-CD Complex | % Practical Yield | % Drug Content | Saturation Solubility (mg/mL) | % Increase in solubility |
| Drug | — | — | 3.14 | — | Physical mixture | | | 8.58 | | Kneading | | | 8.24 | | Co-grounding | | | 8.31 | | Co-evaporation | | | 12.13 | | Melting method | | | 9.17 | | Freeze-Drying | | | 20.71 | | Spray Drying | | | 16.54 | |
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