Serratiopeptidase Niosomal Gel with Potential in Topical Delivery

Table 4

Cumulative amount permeated, flux, and permeability coefficient of SRP across excised rat skin.

Formulation	Cumulative amount permeated (μg/cm^2)	Mean flux (μg/cm^2·hr)	Permeability coefficient (cm^2/hr) × 10^3	Enhancement ratio
SRP solution in Tris-buffer	189.18±1.27	29.7±0.41	59.40±0.82	—
SRP niosomal dispersion	916.22±0.64	68.79±0.35	137.58±0.7	2.32
SRP niosomal gel without DMSO	96.45±1.25	4.12±0.68	8.24±1.37	0.14
SRP niosomal gel with DMSO	316.43±1.5	20.43±0.27	40.87±0.53	0.69