Development and Evaluation of Taste Masked Granular Formulation of Satranidazole by Melt Granulation Technique

Table 2

Composition of batches prepared using selected wax for optimization.

Ingredients	F1	F2	F3	F4
	Ratio of drug : stearic acid
	1 : 1	1 : 1.5	1 : 2	1 : 2.5
	Quantity in mg per dose
Satranidazole	300	300	300	300
Stearic acid	300	450	600	750
Eudragit EPO	100	100	100	100
Starch 1500	200	200	200	200
Magnesium oxide	70	70	70	70
Mannitol	798	648	498	348
Xylitol	42	42	42	42
Sodium CMC	20	20	20	20
HPC	80	80	80	80
Vanilla	20	20	20	20
Aspartame	65	65	65	65
Magnesium stearate	5	5	5	5