Review Article
Lipid-Based Drug Delivery Systems
Table 3
Pouton’s classification of lipid-based delivery systems.
| | Type I | Type II | Type IIIA | Type IIIB |
| % triglycerides or mixed glycerides | 100 | 40–80 | 40–80 | <20 | % surfactants | — | 20–60 (HLB < 12) | 20–40 (HLB > 11) | 20–50 (HLB > 11) | % hydrophilic cosolvents | — | — | 0–40 | 20–50 | Particle size of dispersion (nm) | Coarse | 100–250 | 100–250 | 50–100 | Significance of aqueous dilution | Limited importance | Solvent capacity unaffected | Some loss of solvent capacity | Significant phase changes and potential loss of solvent capacity | Significance of digestibility | Crucial requirement | Not crucial, but likely to occur | Not crucial, but may be inhibited | Not required and not likely to occur |
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