Formulation Development and Evaluation of Fast Disintegrating Tablet of Cetirizine Hydrochloride: A Novel Drug Delivery for Pediatrics and Geriatrics

Table 8

Accelerated stability studies of Cetirizine Hydrochloride FDT stored at 40 ± 2°C/75% RH ± 5%.

	Three primary batches
Time interval	Day 0			The 15th day			The 30th day
Evaluation parameters	B-1	B-2	B-3	B-1	B-2	B-3	B-1	B-2	B-3
*Hardness; (Kg/cm^2) ± SD	1.3±0.58	1.2±0.29	1.8±0.29	1.9±0.29	2.0±0.29	1.5±0.00	3.0±0.5	2.5±0.29	1.7±0.29
Friability (%)	0.1	0.4	0.6	0.3	0.4	0.2	0.1	0.2	0.5
Drug content ± SD	100.8±3.36	95.6±2.34	93.8±1.24	98.5±2.14	99.4±2.67	90.42±3.64	92.8±1.98	99±1.65	97.6±3.63
**Disintegration; time (sec) ± SD	37±4.79	40±3.64	35±2.27	44±2.06	46±2.18	39±3.09	45±3.43	50±3.27	44±2.23

∗Average of three determinations/batch. ∗∗average of six determinations/batch.