Research Article
Formulation and Evaluation of Multilayered Tablets of Pioglitazone Hydrochloride and Metformin Hydrochloride
Table 2
Optimized immediate release layer along with controlled release layer is formulated as bilayer tablets.
| | Formulation code | F5 | F6 | F7 | F8 | F9 | F10 | F11 | F12 | F13 |
| | Immediate release layer | | | | | | | | | | | Pioglitazone HCl (mg) | 15 | 15 | 15 | 15 | 15 | 15 | 15 | 15 | 15 | | Crospovidone (mg) | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | | Avicel PH 102 (mg) | 2.25 | 2.25 | 2.25 | 2.25 | 2.25 | 2.25 | 2.25 | 2.25 | 2.25 | | Lactose (mg) | 57.75 | 57.75 | 57.75 | 57.75 | 57.75 | 57.75 | 57.75 | 57.75 | 57.75 | | Magnesium stearate (mg) | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | | Talc (mg) | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | | Controlled release layer | | | | | | | | | | | Metformin HCl (mg) | 500 | 500 | 500 | 500 | 500 | 500 | 500 | 500 | 500 | | HPMC K4M (mg) | 50 | 75 | 112.5 | 125 | — | — | — | — | — | | Guar gum (mg) | — | — | — | — | 37.5 | 75 | 112.5 | 150 | 112.5 | | PVP K30 (mg) | 25 | 25 | 25 | 25 | 10 | 10 | 10 | 12 | 10 | | Dicalcium phosphate (mg) | 87 | 62 | 24.5 | 12 | 114.5 | 77 | 39.5 | — | 39.5 | | Magnesium stearate (mg) | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | | Talc (mg) | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | | Distilled water | — | — | — | — | Q.S | Q.S | Q.S | Q.S | Q.S | | Barrier layer | | | | | | | | | | | Ethyl cellulose (mg) | — | — | — | — | — | — | — | — | 35 | | Total weight (mg) | 750 | 750 | 750 | 750 | 750 | 750 | 750 | 750 | 785 |
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