Formulation and Evaluation of Multilayered Tablets of Pioglitazone Hydrochloride and Metformin Hydrochloride

Table 5

Flow properties of granules prepared by wet granulation method.

Batch number	Angle of repose	BD (g/mL)	TD (g/mL)	C.I (%)	Hausner’s ratio	Content uniformity (%)	Moisture content (%)	Loss on drying (%)
F9	28.7±0.02	0.56±0.04	0.62±0.09	11.8±0.07	1.107±0.07	102.6±0.04	4.6±0.6	6.2±0.4
F10	26.3±0.07	0.53±0.08	0.59±0.06	13.4±0.04	1.113±0.08	98.8±0.05	5.1±0.2	6.7±0.1
F11	25.8±0.06	0.59±0.01	0.65±0.05	12.6±0.06	1.101±0.05	101.6±0.02	4.3±0.5	6.5±0.8
F12	29.1±0.04	0.55±0.05	0.61±0.02	14.8±0.09	1.109±0.04	98.5±0.05	5.8±0.4	5.9±0.3
F13	25.9±0.08	0.57±0.03	0.63±0.07	12.3±0.07	1.103±0.04	99.8±0.09	4.5±0.7	6.4±0.2