Freeze Dried Quetiapine-Nicotinamide Binary Solid Dispersions: A New Strategy for Improving Physicochemical Properties and Ex Vivo Diffusion

Table 1

Molar ratio composition of QF-NIC coamorphous dispersions.

Formula number	Drug (mg)	Nicotinamide (mg)		Solvent system	Evaporation method
F1	150	41.49	1 : 1	Ethanol	Cold evap.
F2	150	41.49	1 : 1		Cold evap.
F3	150	82.98	1 : 2	Ethanol	Cold evap.
F4	150	82.98	1 : 2		Cold evap.
F5	150	124.47	1 : 3	Ethanol	Cold evap.
F6	150	124.47	1 : 3		Cold evap.

Eth/W: ethanol/water system 50 : 50 v/v; : molar ratio.