Liver Metabolic Alterations and Changes in Host Intercompartmental Metabolic Correlation during Progression of Malaria

Table 1

Metabolites perturbed in the mouse liver during infection with P. berghei ANKA. Italicized metabolites could not be confirmed. Cystine, serine and phosphoserine could not be confirmed because their crosspeaks occur in very crowded regions of the spectrum. Presence of fatty acids cannot be confirmed due to low concentrations.

Increased compound	Chemical; shift	VIP; value	Loading	Decreased compound	Chemical shift	VIP value	Loading
Females early stage
N-methyl-a-aminobutyric acid, Ribonolactone	3.82	3.01	0.242	Beta-alanine	3.18	5.66	−0.455
Dimethylglycine	3.7	2.85	0.229	O-phosphoethanolamine	4.02	2.5	−0.201
Phosphocreatine, Creatine, Betaine	3.9	2.72	0.219	Unidentified	3.66	2.12	−0.171
Unidentified	3.46	2.58	0.207	Sarcosine	3.62	2.84	−0.228
Alanine, methylacetoacetic acid, acetylcholine	3.74	1.91		Choline, Creatinine	4.06	2.37	−0.191
Choline,	3.5	1.5	0.153
3-hydroxyisovaleric acid, 4-pyridoxic acid	2.34	1.62	0.130
Female late stage
2-hydroxy-2-methylbutyric acid	0.94	3.01	0.242	Dimethylglycine	3.7	3.34	−0.268
2-ethylacrylic acid	0.98	2.41	0.194	N-methyl-a-aminobutyric acid, ribonolactone	3.82	3.34	−0.268
Diethyl-thiophosphate,  O-phosphoethanolamine, Phosphoserine	3.98	2.38	0.191	Unconfirmed	3.46	3.28	−0.263
Beta-alanine	3.18	2.21	0.178	N-methyl-a-aminobutyric acid,3-mercaptopyruvic acid	3.86	3.05	−0.245
Dimethyl-sulphide, Acetyl-phosphate,  Amino-acetone, cis-2-methylaconitate	2.10	2.15	0.173	Alanine, methylacetoacetic acid, acetylcholine	3.74	2.73	−0.219
Putrescine, L-leucine,  2-hydroxy-2-methylbutyric acid	1.7	2.03	0.163	Lactate,long chain fatty acids	1.3	2.18	−0.175
3-hydroxyisovaleric acid, 4-pyridoxic acid	2.34	1.87	0.150	Glycine	3.54	2.13	−0.171
2-ethylacrylic acid, stearic acid	1.02	1.82	0.146	lactic acid, N-acetyl-L-alanine	4.1	1.74	−0.140
Males late stage
Beta-alanine, Cystine	3.18	3.26	0.262	N-methyl-a-aminobutyric acid,Ribonolactone	3.82	3.52	−.282
2-hydroxy-2-methyl-butyric acid	0.94	3.00	0.241	N-methyl-a-aminobutyric acid,3-mercaptopyruvic acid	3.86	3.38	−.271
2-ethylacrylic acid	0.98	2.44	0.196	Serine, Dimethylglycine	3.7	3.13	−.251
Dimethyl-sulphide, Acetyl-phosphate,  Amino-acetone, cis-2-methylaconitate	2.1	1.98	0.159	Alanine, methylacetoacetic acid, acetylcholine	3.74	2.99	−.20
Putrescine, 2-hydroxy-2-methylbutyric acid,  L-leucine	1.7	1.95	0.156	Phosphocreatine, Creatine, Betaine	3.9	2.44	−.196
2-ethylacrylic acid, stearic acid	1.02	1.77	0.142	cis-aconitic acid	3.46	2.33	−.187
Long-chain fatty acids	0.9	1.73	0.139	lactic acid, N-acetyl-L-alanine	4.1	1.98	−.160
O-phosphoethanolamine, phosphoserine	3.98	1.73	0.139	Alanine, Acetylcholine, guanidinoacetic acid	3.78	1.71	−.136