About this Journal Submit a Manuscript Table of Contents
Journal of Parasitology Research
Volume 2012 (2012), Article ID 296856, 11 pages
http://dx.doi.org/10.1155/2012/296856
Clinical Study

The Effect of Antihelminthic Treatment on Subjects with Asthma from an Endemic Area of Schistosomiasis: A Randomized, Double-Blinded, and Placebo-Controlled Trial

1Serviço de Imunologia, Universidade Federal da Bahia (UFBA), 40110-160 Salvador, BA, Brazil
2Departamento de Ciências da Vida, Universidade do Estado da Bahia UNEB, 41.150-000 Salvador, BA, Brazil
3Instituto Nacional de Ciências e Tecnologia em Doenças Tropicais (INCT-DT/CNPq-MCT), Brazil
4ProAR, Núcleo de Excelência em Asma, Universidade Federal da Bahia 40110-160 Salvador, BA, Brazil
5Faculdade de Farmácia, UFBA 40110-160 Salvador, BA, Brazil
6Escola Bahiana de Medicina e Saúde Pública, EBMSP, Salvador, Bahia, Brazil

Received 14 April 2012; Revised 15 June 2012; Accepted 21 June 2012

Academic Editor: Elena Pinelli

Copyright © 2012 Maria Cecilia F. Almeida et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. N. R. Lynch, I. A. Hagel, M. E. Palenque et al., “Relationship between helminthic infection and IgE response in atopic and nonatopic children in a tropical environment,” Journal of Allergy and Clinical Immunology, vol. 101, no. 2 I, pp. 217–221, 1998. View at Publisher · View at Google Scholar · View at Scopus
  2. I. Hagel, N. R. Lynch, M. Perez, M. C. di Prisco, R. Lopez, and E. Rojas, “Modulation of the allergic reactivity of slum children by helminthic infection,” Parasite Immunology, vol. 15, no. 6, pp. 311–315, 1993. View at Scopus
  3. M. I. Araujo, A. A. Lopes, M. Medeiros et al., “Inverse association between skin response to aeroallergens and Schistosoma mansoni infection,” International Archives of Allergy and Immunology, vol. 123, no. 2, pp. 145–148, 2000. View at Scopus
  4. M. Medeiros Jr., J. P. Figueiredo, M. C. Almeida et al., “Schistosoma mansoni infection is associated with a reduced course of asthma,” Journal of Allergy and Clinical Immunology, vol. 111, no. 5, pp. 947–951, 2003. View at Publisher · View at Google Scholar · View at Scopus
  5. R. Hussain, R. W. Poindexter, and E. A. Ottesen, “Control of allergic reactivity in human filariasis: Predominant localization of blocking antibody to the IgG4 subclass,” Journal of Immunology, vol. 148, no. 9, pp. 2731–2737, 1992. View at Scopus
  6. A. H. J. van den Biggelaar, R. van Ree, L. C. Rodrigues et al., “Decreased atopy in children infected with Schistosoma haematobium: a role for parasite-induced interleukin-10,” The Lancet, vol. 356, no. 9243, pp. 1723–1727, 2000. View at Scopus
  7. B. Royer, S. Varadaradjalou, P. Saas, J. J. Guillosson, J. P. Kantelip, and M. Arock, “Inhibition of IgE-induced activation of human mast cells by IL-10,” Clinical and Experimental Allergy, vol. 31, no. 5, pp. 694–704, 2001. View at Publisher · View at Google Scholar · View at Scopus
  8. M. I. Asher and S. K. Weiland, “The international study of asthma and allergies in childhood (ISAAC),” Clinical and Experimental Allergy, Supplement, vol. 28, no. 5, pp. 52–66, 1998. View at Scopus
  9. S. Stanojevic, A. Wade, J. Stocks et al., “Reference ranges for spirometry across all ages: a new approach,” American Journal of Respiratory and Critical Care Medicine, vol. 177, no. 3, pp. 253–260, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. N. Katz, P. M. Coelho, and J. Pellegrino, “Evaluation of Kato's quantitative method through the recovery of Schistosoma mansoni eggs added to human feces,” Journal of Parasitology, vol. 56, no. 5, pp. 1032–1033, 1970. View at Scopus
  11. D. E. Elliott, J. Li, A. Blum et al., “Exposure to schistosome eggs protects mice from TNBS-induced colitis,” American Journal of Physiology, vol. 284, no. 3, pp. G385–G391, 2003. View at Scopus
  12. L. G. G. Pacífico, F. A. V. Marinho, C. T. Fonseca et al., “Schistosoma mansoni antigens modulate experimental allergic asthma in a murine model: a major role for CD4+ CD25+ Foxp3+ T cells independent of interleukin-10,” Infection and Immunity, vol. 77, no. 1, pp. 98–107, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. H. M. Mo, J. H. Lei, Z. W. Jiang et al., “Schistosoma japonicum infection modulates the development of allergen-induced airway inflammation in mice,” Parasitology Research, vol. 103, no. 5, pp. 1183–1189, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. J. Leonardi-Bee, D. Pritchard, and J. Britton, “Asthma and current intestinal parasite infection: systematic review and meta-analysis,” American Journal of Respiratory and Critical Care Medicine, vol. 174, no. 5, pp. 514–523, 2006. View at Publisher · View at Google Scholar · View at Scopus
  15. C. Flohr, S. K. Weiland, G. Weinmayr et al., “The role of atopic sensitization in flexural eczema: findings from the international study of asthma and allergies in childhood phase two,” Journal of Allergy and Clinical Immunology, vol. 121, no. 1, pp. 141–147, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. P. Bager, J. Arnved, S. Rønborg et al., “Trichuris suis ova therapy for allergic rhinitis: a randomized, double-blind, placebo-controlled clinical trial,” Journal of Allergy and Clinical Immunology, vol. 125, no. 1–3, pp. 123–130, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. C. Flohr, L. N. Tuyen, R. J. Quinnell et al., “Reduced helminth burden increases allergen skin sensitization but not clinical allergy: a randomized, double-blind, placebo-controlled trial in Vietnam,” Clinical and Experimental Allergy, vol. 40, no. 1, pp. 131–142, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. J. Feary, J. Britton, and J. Leonardi-Bee, “Atopy and current intestinal parasite infection: a systematic review and meta-analysis,” Allergy, vol. 66, no. 4, pp. 569–578, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. D. W. Dunne and A. Cooke, “A worm's eye view of the immune system: consequences for evolution of human autoimmune disease,” Nature Reviews Immunology, vol. 5, no. 5, pp. 420–426, 2005. View at Publisher · View at Google Scholar · View at Scopus
  20. H. Mpairwe, E. L. Webb, L. Muhangi et al., “Anthelminthic treatment during pregnancy is associated with increased risk of infantile eczema: randomised-controlled trial results,” Pediatric Allergy and Immunology, vol. 22, no. 3, pp. 305–312, 2011. View at Publisher · View at Google Scholar · View at Scopus
  21. S. H. Cho, L. A. Stanciu, S. T. Holgate, and S. L. Johnston, “Increased interleukin-4, interleukin-5, and interferon-γ in airway CD4+ and CD8+ T cells in atopic asthma,” American Journal of Respiratory and Critical Care Medicine, vol. 171, no. 3, pp. 224–230, 2005. View at Publisher · View at Google Scholar · View at Scopus
  22. R. Stephens, D. A. Randolph, G. Huang, M. J. Holtzman, and D. D. Chaplin, “Antigen-nonspecific recruitment of Th2 cells to the lung as a mechanism for viral infection-induced allergic asthma,” Journal of Immunology, vol. 169, no. 10, pp. 5458–5467, 2002. View at Scopus
  23. L. S. Cardoso, S. C. Oliveira, A. M. Góes et al., “Schistosoma mansoni antigens modulate the allergic response in a murine model of ovalbumin-induced airway inflammation,” Clinical and Experimental Immunology, vol. 160, no. 2, pp. 266–274, 2010. View at Publisher · View at Google Scholar · View at Scopus
  24. L. S. Cardoso, S. C. Oliveira, A. M. Góes et al., “Schistosoma mansoni antigens modulate the allergic response in a murine model of ovalbumin-induced airway inflammation,” Clinical and Experimental Immunology, vol. 160, no. 2, pp. 266–274, 2010. View at Publisher · View at Google Scholar · View at Scopus
  25. M. I. A. S. Araujo, B. Hoppe, M. Medeiros Jr. et al., “Impaired T helper 2 response to aeroallergen in helminth-infected patiente with asthma,” Journal of Infectious Diseases, vol. 190, no. 10, pp. 1797–1803, 2004. View at Publisher · View at Google Scholar · View at Scopus
  26. L. E. P. M. van der Vlugt, L. A. Labuda, A. Ozir-Fazalalikhan et al., “Schistosomes induce regulatory features in human and mouse CD1dhi B cells: inhibition of allergic inflammation by IL-10 and regulatory T cells,” Plos One, vol. 7, no. 2, Article ID e30883, 2012. View at Publisher · View at Google Scholar
  27. K. Kitagaki, T. R. Businga, D. Racila, D. E. Elliott, J. V. Weinstock, and J. N. Kline, “Intestinal helminths protect in a murine model of asthma,” Journal of Immunology, vol. 177, no. 3, pp. 1628–1635, 2006. View at Scopus
  28. D. T. Deurloo, B. C. A. M. van Esch, C. L. Hofstra, F. P. Nijkamp, and A. J. M. van Oosterhout, “CTLA4-IgG reverses asthma manifestations in a mild but not in a more “severe” ongoing murine model,” American Journal of Respiratory Cell and Molecular Biology, vol. 25, no. 6, pp. 751–760, 2001. View at Scopus
  29. S. Tsuyuki, J. Tsuyuki, K. Einsle, M. Kopf, and A. J. Coyle, “Costimulation through B7-2 (CD86) is required for the induction of a lung mucosal T helper cell 2 (Th2) immune response and altered airway responsiveness,” Journal of Experimental Medicine, vol. 185, no. 9, pp. 1671–1679, 1997. View at Publisher · View at Google Scholar · View at Scopus
  30. R. R. Oliveira, K. J. Gollob, J. P. Figueiredo et al., “Schistosoma mansoni infection alters co-stimulatory molecule expression and cell activation in asthma,” Microbes and Infection, vol. 11, no. 2, pp. 223–229, 2009. View at Publisher · View at Google Scholar · View at Scopus
  31. L. M. Araujo, J. Lefort, M. A. Nahori et al., “Exacerbated Th2-mediated airway inflammation and hyperresponsiveness in autoimmune diabetes-prone NOD mice: a critical role for CD1d-dependent NKT cells,” European Journal of Immunology, vol. 34, no. 2, pp. 327–335, 2004. View at Publisher · View at Google Scholar · View at Scopus