Table 2: Levels of cytokines in supernatants of PBMC cultures in the studied subjects.

CytokineAntigenD0D7D90
G1/placeboG2/PZQG1/placeboG2/PZQG1/placeboG2/PZQ


IFN-γ
Without stimulus32.7 (31.2–276.0)31.6 (31.2–91.0)31.2 (31.2–46.7)39.7 (31.2–583.6)31.2 (31.2–130.7)32.7 (31.2–2563.0)
SWAP149.5 (42.0–10337.0)88.0 (31.2–2092.0)56.0 (43.8–1415.0)137.8 (37.4–15543.0)70.0 (15.6–3329.0)130.7 (31.2–2563.0)
Der p1338.5 (102.4–7475.0)710.0 (149.0–2568.0)116.7 (42.0–420.2)333.9 (32.7–9669.0)201.0 (31.2–4818.0)149.4 (15.6–1275.0)


IL-5
Without stimulus15.6 (15.6–112.0)15.6 (15.6-15.6)15.6 (15.6-15.6)15.6 (15.6–40.7)15.6 (15.6–25.0)15.6 (15.6–635.0)
SWAP468.5 (15.6–5156.0)310.2 (15.6–5904.0)542.0 (15.6–4444.0)1863.0 (15.6–4606.0)1670.0 (21.5–4444.0)2850 (136.0–4444.0)
Der p1150.0 (15.6–630.0)a463.0 (207.0–4606.0)a28.8 (15.6–407.4)60.0 (15.6–4606.0)28.7 (15.6–1720.0)352.0 (15.6–3509.0)


IL-10
Without stimulus27.5 (15.6–475.0)28.0 (15.6–102.0)57.0 (16.8–589.0)23.1 (15.6–1144.0)36.0 (15.6–446.9)15.6 (15.6–127.0)
SWAP264.5 (26.0–1688.0)642.0 (125.0–1132.0)b288.0 (29.4–641.0)667.3 (15.6–2447.0)240.0 (21.1–638.4)175.6 (60.3–1062.0)b
Der p1451.0 (56.0–1060.0)349.0 (177.0–1539.0)924.0 (297.1–2063.0)288.0 (15.6–2086.0)390.0 (54.3–1744.0)204.0 (60.0–638.0)

Data showed as median (minimum and maximum values) pg/ml;
aPlacebo D0 versus PZQ D0 𝑃 < 0 . 0 5 (Mann-Whitney 𝑡 -test);
bPZQ D0 versus PZQ D90 𝑃 < 0 . 0 5 (Wilcoxon matched-pairs signs ranks test).