Schistosoma Tegument Proteins in Vaccine and Diagnosis Development: An Update

Table 1

Schistosome tegument protein evaluated as vaccine candidates in preclinical studies.

Protein	Vaccine type	Protection level	Egg reduction	Bioinformatic tool used in antigen selection	References
Sm 21.7	Recombinant protein	41%–70%	ND	ND	[63]
Sm 21.7	DNA vaccine	41.5%	62% (liver); 67% (intestine)	ND	[64]
Cu/Zn superoxide dismutase	DNA vaccine	44%–60%	ND	ND	[65]
Sm TSP2	Recombinant protein	57%	64% (liver); 65% (feces)	BLAST	[57, 83]
Sm29	Recombinant protein	51%	60% (intestine)	InterProScan, SignalIP 3.0, Signal IP Neural, NetNGlyc 1.0, BLAST, WolfpSORT, SOSUI, Compute pI/Mw tool,	[49, 50]
ECL (200 kDa protein)	DNA vaccine	38.1%	ND	ND	[61]
Sm 22.6	Recombinant protein	34.5%	ND	BLAST	[53]
Sm TSP 1	Recombinant protein	34%	52% (liver); 69% (intestine)	BLAST	[57, 83]

ND: not determined.