Host-Parasite Interaction: Parasite-Derived and -Induced Proteases That Degrade Human Extracellular Matrix

Table 3

Intracellular parasite induced proteases that degrade human ECM proteins.

Parasite	Protease	Type	ECM substrates				Localization	Reference
			Collagen	Fibronectin	Laminin	Elastin
Toxoplasma gondii	MMP-9 or gelatinase B	MMP	IV, V, XI, XIV	ND	Yes	Yes	Infected macrophage surface and secreted	[153, 205–207]
	MT1-MMP or MMP-14	MT-MMP	I, II, III	Yes	Yes	ND	Infected macrophage surface	[153, 204, 205, 208]
	MMP-2 or gelatinase A	MMP	I, II, III, IV, V, VII, X, XI	Yes	Yes	Yes	Secreted by unknown host cell	[153, 207, 209]
	MMP-12 or macrophage elastase	MMP	I, IV, V	Yes	Yes	Yes	Secreted by unknown host cell	[153, 207, 210, 211]
Plasmodium falciparum	MMP-9 or gelatinase B	MMP	IV, V, XI, XIV	ND	Yes	Yes	Secreted by unknown host cell	[153, 212]
	MMP-8	MMP	I, II, III	ND	ND	ND	Secreted by unknown host cell	[153, 213]

MT1-MMP: membrane-type MMP.