Treatment of <i>Plasmodium chabaudi</i> Parasites with Curcumin in Combination with Antimalarial Drugs: Drug Interactions and Implications on the Ubiquitin/Proteasome System

<table>Isobologram illustrating the <i>in vivo</i> interaction at the ED90 level between drug A (curcumin-piperine) with drug B (chloroquine) in <i>Plasmodium chabaudi</i> AS-3CQ chloroquine-resistant parasites. Plotting the percentage parasitemia inhibition versus the log dose of the drugs either alone and the drugs in combination using GraphPad Prism 4 software yielded a regression equation. The equation allowed the determination of the ED90 of the drugs alone and the drugs in combination. ED90 values were used to obtain isobolar equivalents (IE) [<a href="/journals/jpr/2013/429736/#B29">25</a>, <a href="/journals/jpr/2013/429736/#B30">26</a>]. </table>

Journal of Parasitology Research

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Figure 2: Treatment of <i>Plasmodium chabaudi</i> Parasites with Curcumin in Combination with Antimalarial Drugs: Drug Interactions and Implications on the Ubiquitin/Proteasome System 

Figure 2 | Treatment of Plasmodium chabaudi Parasites with Curcumin in Combination with Antimalarial Drugs: Drug Interactions and Implications on the Ubiquitin/Proteasome System 