Treatment of Plasmodium chabaudi Parasites with Curcumin in Combination with Antimalarial Drugs: Drug Interactions and Implications on the Ubiquitin/Proteasome System
Figure 3
Parasitemia evolution in mice infected with P. chabaudi clone AS-ART treated with: artemisinin, curcumin, curcumin/piperine, and curcumin/piperine/artemisinin. Drugs were administered by oral gavage for 4 consecutive days and parasitemia was followed every day following drug treatment for 7 consecutive days. Results represent the mean parasitemia ± S.D. #Significant difference was found between the artemisinin only treatment group (150 mg/kg) versus the curcumin, curcumin/piperine, and curcumin/piperine/artemisinin. *Significant difference was found () between the curcumin/piperine group versus the curcumin only treatment group and the curcumin/piperine/chloroquine.
