Research Article

Treatment of Plasmodium chabaudi Parasites with Curcumin in Combination with Antimalarial Drugs: Drug Interactions and Implications on the Ubiquitin/Proteasome System

Table 1

Acute toxicity test for curcumin. Mice were allowed to fast 4 hours. After 4 hours a single dose of curcumin was orally administered in different concentrations to BALB/c infected mice. Mice were observed for 14 days for any physical signs of toxicity.

LD50 cytotoxicity test WeightSurvival (days)

2,0 g per kg of body weight15 g14 days
2,5 per kg of body weight 15 g10 days
3,0 g per kg of body weight15 g5 days
3,5 g per kg of body weight15 g3 days
5,0 g per kg of body weight15 g1 day