In Vitro and In Vivo Antimalarial Activity of Ficus thonningii Blume (Moraceae) and Lophira alata Banks (Ochnaceae), Identified from the Ethnomedicine of the Nigerian Middle Belt

Table 2

In vivo antimalarial activity of hexane extracts of F. thonningii and L. alata against P. berghei NK65 infected Swiss albino mice.

Drug/extract	Dose mg/kg	Mean ± SD parasitemia (%)	Percent suppression of parasitemia	Mean survival time (days)
F. thonningii	100	3.8±0.4	65.1	10±1.0
	200	3.1±0.3	70.6	12.3±0.6
	300	2.1±0.2	76.3	14.3±1.5
	400	1.5±0.3	83.4	16.6±0.5
	500	1.2±0.4	84.5	22.3±1.5
L. alata	100	6.7±0.8	23.6	7±1.7
	200	6.0±1.1	36.9	9.3±1.1
	300	4.1±0.6	59.7	10±1.0
	400	3.0±0.5	68.9	12±1.3
	500	2.3±0.4	74.4	15±2.0
CQ		0.8±0.2	89.3	>30
Saline/10% Tween 80		10.9±1.2		8.3±0.6

The results are expressed as mean ± SD of three determinations per experiment. Experiments were performed twice.