Research Article
The Transmission Disequilibrium/Heterogeneity Test with Parental-Genotype Reconstruction for Refined Genetic Mapping of Complex Diseases
Table 9
Powers of the RC-TDT and RC-TDH in simulation study 2.
| | Scenario | | Dominant | Recessive | Additive | Multiplicative | | RC-TDT | RC-TDH | RC-TDT | RC-TDH | RC-TDT | RC-TDH | RC-TDT | RC-TDH |
| | | 0.0 | 0.00 | 0.65 | 0.00 | 0.37 | 0.00 | 0.19 | 0.00 | 0.13 | | | 0.2 | 0.10 | 0.82 | 0.02 | 0.53 | 0.03 | 0.35 | 0.01 | 0.25 | | S1 | 0.4 | 0.57 | 0.96 | 0.37 | 0.85 | 0.33 | 0.72 | 0.25 | 0.63 | | | 0.6 | 0.98 | 1.00 | 0.86 | 1.00 | 0.87 | 0.98 | 0.78 | 0.94 | | | 0.8 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 0.99 | 1.00 | | | 1.0 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| | S5 | 0.0 | 0.00 | 0.17 | 0.00 | 0.04 | 0.00 | 0.01 | 0.00 | 0.01 | | 0.2 | 0.02 | 0.27 | 0.00 | 0.09 | 0.01 | 0.10 | 0.00 | 0.06 | | 0.4 | 0.25 | 0.62 | 0.04 | 0.29 | 0.16 | 0.43 | 0.06 | 0.24 | | 0.6 | 0.79 | 0.93 | 0.22 | 0.53 | 0.65 | 0.81 | 0.40 | 0.62 | | 0.8 | 0.99 | 1.00 | 0.61 | 0.89 | 0.96 | 0.99 | 0.81 | 0.94 | | 1.0 | 1.00 | 1.00 | 0.89 | 0.99 | 1.00 | 1.00 | 0.97 | 0.99 |
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In this simulation, we used 50% families with available parental marker genotypes and 50% families without parental marker genotypes.
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