Predicting Disease Onset from Mutation Status Using  Proband and Relative Data with Applications to Huntington's Disease

<table>Estimated CDF of age-at-first-symptom of HD for <svg height="14.8375" id="M131" style="vertical-align:-3.2316pt" version="1.1" viewbox="0 0 94.650002 14.8375" width="94.650002" xmlns="http://www.w3.org/2000/svg">
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<tspan style="font-size: 12.50px; " x="0" y="0">𝐴</tspan>
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<tspan style="font-size: 8.75px; " x="0" y="0">𝑖</tspan>
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<tspan style="font-size: 12.50px; " x="0" y="0">=</tspan>
<tspan style="font-size: 12.50px; " x="12.027886" y="0">4</tspan>
<tspan style="font-size: 12.50px; " x="18.279387" y="0">1</tspan>
<tspan style="font-size: 12.50px; " x="24.530886" y="0">,</tspan>
<tspan style="font-size: 12.50px; " x="29.744637" y="0">4</tspan>
<tspan style="font-size: 12.50px; " x="35.996136" y="0">3</tspan>
<tspan style="font-size: 12.50px; " x="42.247639" y="0">,</tspan>
<tspan style="font-size: 12.50px; " x="47.448887" y="0">4</tspan>
<tspan style="font-size: 12.50px; " x="53.700386" y="0">6</tspan>
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</svg>, and 50 with COHORT combined proband and relative data.</table>

Journal of Probability and Statistics

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Figure 5

Figure 5: Predicting Disease Onset from Mutation Status Using  Proband and Relative Data with Applications to Huntington's Disease 