Predicting Disease Onset from Mutation Status Using Proband and Relative Data with Applications to Huntington's Disease

Table 2

Simulation 2 (combined proband and relative data). Estimated CDF and standard errors from the EM algorithm with combined proband and family analysis, 𝑛=4000, 1000 replications.

	CAG = 41				CAG = 46				CAG = 50
Age	𝐹(𝑡∣𝐴𝑖)	Mean 𝐹(𝑡∣𝐴𝑖)	Empi: sd	Mean sd	𝐹(𝑡∣𝐴𝑖)	Mean 𝐹(𝑡∣𝐴𝑖)	Empi: sd	Mean sd	𝐹(𝑡∣𝐴𝑖)	Mean 𝐹(𝑡∣𝐴𝑖)	Empi: sd	Mean sd
10	0.0006	0.0006	0.0002	0.0002	0.0010	0.0010	0.0002	0.0002	0.0025	0.0026	0.0008	0.0008
20	0.0028	0.0029	0.0007	0.0007	0.0102	0.0102	0.0014	0.0014	0.0373	0.0374	0.0069	0.0068
30	0.0134	0.0137	0.0023	0.0023	0.0928	0.0928	0.0069	0.0070	0.3754	0.3751	0.0241	0.0238
40	0.0609	0.0616	0.0069	0.0069	0.5041	0.5042	0.0148	0.0143	0.9031	0.9030	0.0139	0.0132
50	0.2373	0.2378	0.0149	0.0146	0.9099	0.9100	0.0076	0.0074	0.9931	0.9930	0.0020	0.0019
60	0.5987	0.5979	0.0200	0.0188	0.9901	0.9901	0.0015	0.0014	0.9996	0.9995	0.0002	0.0002
70	0.8773	0.8761	0.0133	0.0125	0.9990	0.9990	0.0002	0.0002	1.0000	1.0000	0.0000	0.0000
80	0.9717	0.9710	0.0050	0.0047	0.9999	0.9999	0.0000	0.0000	1.0000	1.0000	0.0000	0.0000
90	0.9940	0.9937	0.0015	0.0014	1.0000	1.0000	0.0000	0.0000	1.0000	1.0000	0.0000	0.0000