Research Article

A Two-Stage Penalized Logistic Regression Approach to Case-Control Genome-Wide Association Studies

Table 5

The simulated average PDR and FDR under Model 4: significant interaction effect but zero marginal effects.

( 𝑛 , 𝑃 ) 𝜉 1 2 𝑞 PDRFDR
TPLR MT TPLR MT

(800,1000)  1.90.1 0.8280.702 0.012 0 . 5 5 0
2.00.1 0.9450.860 0.026 0 . 6 4 1
2.10.1 0.9650.915 0.015 0 . 9 1 5

(800,5000)  1.90.1 0.5550.460 0.009 0 . 4 0 6
2.00.1 0.7300.710 0.014 0 . 4 2 7
2.10.1 0.8850.795 0.006 0 . 5 6 2