The clinical trial, a prospective study to evaluate the effect of interventions in humans under prespecified conditions, is a standard and integral part of modern medicine. Many adaptive and sequential approaches have been proposed for use in clinical trials to allow adaptations or modifications to aspects of a trial after its initiation without undermining the validity and integrity of the trial. The application of adaptive and sequential methods in clinical trials has significantly improved the flexibility, efficiency, therapeutic effect, and validity of trials.

To further advance the performance of clinical trials and convey the progress of research on adaptive and sequential methods in clinical trial design, we invite authors to submit original research and review articles that focus on adaptive and sequential methods in the design of clinical trials. We are especially interested in articles that explore novel adaptive and sequential approaches and their applications in clinical trials. Potential topics include, but are not limited to:

• Bayesian and frequentist adaptive designs of clinical trials
• Bayesian adaptive dose-finding approaches
• Group sequential designs in clinical trials
• Biomarker adaptive designs in clinical trials
• Sample size adjustable designs in clinical trials
• Bayesian adaptive methods for monitoring clinical trials
• Adaptive randomization in clinical trials
• Approaches supporting personalized medicine in trials, including identifying the patient-specific maximum tolerated dose

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/jps/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable: